Which transtubular potassium gradient (TTKG) findings indicate aldosterone deficiency or resistance in metabolic acidosis?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print
Answer

A TTKG of greater than 8 indicates that aldosterone is present and that the collecting duct is responsive to it. A TTKG of less than 5 in the presence of hyperkalemia indicates aldosterone deficiency or resistance. For the test to be interpretable, the urine Na+ level should be greater than 10 mEq/L and the urine osmolality should be greater than or equal to serum osmolality.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!