What is the role of transtubular potassium gradient (TTKG) testing in the workup of metabolic acidosis?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Measuring the transtubular potassium gradient (TTKG; see the calculation below) is useful in determining the etiology of hyperkalemia or hypokalemia associated with metabolic acidosis.

TTKG = urine K+ × serum osmolality/serum K+ × urine osmolality

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