What is the role of salicylates in high-anion gap (AG) acidosis?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Deliberate or accidental ingestion of salicylates can produce a high-AG acidosis, although respiratory alkalosis is usually the more pronounced acid-base disorder.

The increase in AG is only partly from the unmeasured salicylate anion. Increased ketoacid and lactic acid levels have been reported in persons with salicylate overdose and are thought to account for the remainder of the AG.

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