What causes type 4 renal tubular acidosis (RTA)?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print
Answer

The following are causes of type 4 RTA:

  • Hypoaldosteronism (low renin) - Hyporeninemic hypoaldosteronism (diabetes mellitus/mild renal impairment, chronic interstitial nephritis, nonsteroidal anti-inflammatory drugs, beta-blockers)

  • Hypoaldosteronism (high renin) - Primary adrenal defect (isolated: congenital hypoaldosteronism; generalized: Addison disease, adrenalectomy, AIDS), inhibition of aldosterone secretion (heparin, ACE inhibitors, AT1 receptor blockers)

  • Aldosterone resistance (drugs) - Diuretics (amiloride, triamterene, spironolactone), calcineurin inhibitors (cyclosporine, tacrolimus), antibiotics (trimethoprim, pentamidine)

  • Aldosterone resistance (genetic) - Pseudohypoaldosteronism (PHA) types I and II


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!