What are the causes of proximal (type 2) renal tubular acidosis (RTA)?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The following are causes of proximal RTA:

  • Primary - Genetic or sporadic

  • Inherited systemic disease - Wilson disease, glycogen storage disease, tyrosinemia, Lowe syndrome, cystinosis, fructose intolerance

  • Related to other systemic disease - Multiple myeloma, amyloidosis, hyperparathyroidism, Sjögren syndrome

  • Drug- and toxin-related - Carbonic anhydrase inhibitors, ifosfamide, gentamicin, valproic acid, lead, mercury, streptozotocin

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