What are the symptoms of type 2 renal tubular acidosis (RTA)?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Patients with type 2 RTA typically have hypokalemia and increased urinary K+ wasting. This is thought, in part, to be due to an increased rate of urine flow to the distal nephron caused by the reduced proximal HCO3- reabsorption and, in part, to be due to activation of the renin-angiotensin-aldosterone axis with increased collecting duct Na+ reabsorption from the mild hypovolemia induced by bicarbonaturia. Administration of alkali in those patients leads to more HCO3- wasting and can worsen hypokalemia unless K+ is replaced simultaneously.


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