What is the role of the proximal tubule in the pathogenesis of Fanconi syndrome?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

The proximal tubule is the site where bulk reabsorption of ultrafiltrate occurs, driven by the basolateral Na+/K+ –ATPase. Any disorder that leads to decreased ATP production or a disorder involving Na+ -K+ –ATPase can result in Fanconi syndrome. In principle, loss of function of the apical Na+/H+ antiporter or the basolateral Na+/3HCO3- cotransporter or the intracellular carbonic anhydrase results in selective reduction in HCO3- reabsorption.


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