What are the causes of distal renal tubular acidosis (RTA) (type 1)?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The causes of distal RTA are shown as follows. Type 1 RTA occurs sporadically, although genetic forms have been reported.

  • Primary - Genetic or sporadic

  • Drug-related - Amphotericin B, lithium, analgesics, ifosfamide, topiramate, toluene

  • Autoimmune disease - Systemic lupus erythematosus, chronic active hepatitis, Sjögren syndrome, rheumatoid arthritis, primary biliary cirrhosis

  • Related to other systemic disease - Sickle cell disease, hyperparathyroidism, light chain disease, cryoglobulinemia, Wilson disease, Fabry disease

  • Tubulointerstitial disease - Obstructive uropathy, transplant rejection, medullary cystic kidney disease, hypercalciuria

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