What does high urine pH in patients with type 2 renal tubular acidosis (RTA) suggest?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Urine AG is positive and urine pH is high secondary to the renal acid secretion defect. Urine pH also can be high in patients with type 2 RTA if their serum HCO3- level is higher than the renal threshold for reabsorption, typically when a patient with type 2 RTA is on HCO3- replacement therapy. Administration of an HCO3- load leads to a marked increase in urine pH in those who have type 2 RTA, while those with type 1 RTA have a constant urine pH unless their acidosis is overcorrected.

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