How does a defect in Na+ reabsorption cause distal renal tubular acidosis (RTA) (type 1) in patients with metabolic acidosis?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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A defect in Na+ reabsorption in the collecting duct would decrease the electrical gradient favoring the secretion of H+ into the tubular lumen (ie, voltage-dependent defect). This can occur, for instance, in severe volume depletion with decreased luminal Na+ delivery to this site.

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