How is metabolic acidosis classified in relation to the anion gap (AG)?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The reaction below indicates that the addition of an acid (HA, where H+ is combined with an unmeasured anion A-) results in the consumption of HCO3- with an addition of anions that will account for the increase in the AG. Metabolic acidosis is classified on the basis of AG into normal- (also called non-AG or hyperchloremic metabolic acidosis  [4] ) and high-AG metabolic acidosis.

HA + NaHCO3 ↔NaA + H2 CO3 ↔CO2 + H2 O

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