What is titratable acidity?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The amount of secreted H+ that is buffered by filtered weak acids is called titratable acidity. Phosphate as HPO42- is the main buffer in this system, but other urine buffers include uric acid and creatinine.

H2 PO4 ↔H+ + HPO42-

The amount of phosphate filtered is limited and relatively fixed, and only a fraction of the secreted H+ can be buffered by HPO42-.

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