What is the role of pH level maintenance in the pathogenesis of metabolic acidosis?

Updated: Oct 10, 2018
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

To maintain normal pH, the kidneys must perform two physiologic functions. The first is to reabsorb all the filtered HCO3- (any loss of HCO3- is equal to the addition of an equimolar amount of H+), a function principally of the proximal tubule. The second is to excrete the daily H+ load (loss of H+ is equal to addition of an equimolar amount of HCO3-), a function of the collecting duct.


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