What processes must take place to maintain a physiologic [H+] of 40 nEq/L?

Updated: Dec 08, 2020
  • Author: Christie P Thomas, MBBS, FRCP, FASN, FAHA; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Under normal conditions, acids and, to a lesser extent, bases are being added constantly to the extracellular fluid compartment, and for the body to maintain a physiologic [H+] of 40 nEq/L, the following three processes must take place:

  • Buffering by extracellular and intracellular buffers

  • Alveolar ventilation, which controls PaCO2

  • Renal H+ excretion, which controls plasma HCO3-

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