What are the guidelines regarding treatment of chronic hyponatremia?

Updated: Jun 17, 2019
  • Author: Eric E Simon, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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To avoid osmotic demyelination syndrome (ODS) in patients with chronic hyponatremia (known duration >48 hours), the recommendations include the following [34] :

  • Minimum correction of serum sodium by 4-8 mmol/L per day, with a lower goal of 4-6 mmol/L per day if the risk of ODS is high
  • For patients at high risk of ODS: maximum correction of 8 mmol/L in any 24-hour period
  •  For patients at normal risk of ODS: maximum correction of 10-12 mmol/L in any 24-hour period; 18 mmol/L in any 48-hour period

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