What does serum osmolality indicate regarding hyponatremia?

Updated: Jun 17, 2019
  • Author: Eric E Simon, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Serum osmolality readily differentiates between true hyponatremia and pseudohyponatremia secondary to hyperlipidemia, hyperproteinemia, or hypertonic hyponatremia. Sources of hypertonic hyponatremia include elevations of the following:

  • Glucose

  • Mannitol

  • Glycine (after urologic or gynecologic procedures)

  • Sucrose

  • Maltose (contained in IgG formulations)

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