What are the causes of normovolemic (euvolemic) hypotonic hyponatremia?

Updated: Jun 17, 2019
  • Author: Eric E Simon, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

This is a very common cause of hyponatremia in patients who are hospitalized. It is associated with nonosmotic and non–volume-related ADH secretion (ie, SIADH) secondary to a variety of clinical conditions, including the following:

  • CNS disturbances (eg, hypopituitarism [21] )
  • Major surgery
  • Trauma
  • Pulmonary tumors
  • Infection
  • Stress
  • Certain medications

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