What is the treatment for patients with a large osmolal gap due to excess organic solute?

Updated: Jun 17, 2019
  • Author: Eric E Simon, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The presence of a relatively large osmolal gap due to excess organic solute is diagnostic in the appropriate clinical setting. Symptomatic patients are treated depending on plasma osmolality and volume status, with hypertonic saline for patients in hypoosmolar state or a loop diuretic in volume-overloaded patients with normal renal function.

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