Which medications in the drug class ACE Inhibitors are used in the treatment of Hypokalemia?

Updated: Dec 06, 2018
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

ACE Inhibitors

These agents inhibit the production of aldosterone and decrease renal potassium losses. All of the drugs in this category work in the same way. Differences are in the duration of action and the ability to inhibit locally produced and circulating ACE.

Captopril (Capoten, Captoril)

This agent prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in lower aldosterone secretion and increased renin activity. Captopril is the shortest-acting ACE inhibitor; it must be given 2 or 3 times daily, while other drugs in this class can be taken once daily.

Enalapril (Vasotec)

Enalapril is a competitive inhibitor of ACE. It reduces angiotensin II levels, decreasing aldosterone secretion and increasing renin secretion.

Fosinopril

Fosinopril prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in lower aldosterone secretion and increased renin secretion.

Ramipril (Altace)

Ramipril prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, resulting in lower aldosterone secretion.


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