Which medications in the drug class Diuretics, Potassium-Sparing are used in the treatment of Hypokalemia?

Updated: Dec 06, 2018
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Diuretics, Potassium-Sparing

Potassium-sparing diuretics are excellent for adjunctive therapy when ongoing renal losses are anticipated. These agents may be used in conjunction with thiazide or loop diuretics.

Triamterene (Dyrenium)

Triamterene is a potassium-sparing diuretic with relatively weak natriuretic properties. It exerts a diuretic effect on the distal renal tubule, inhibiting reabsorption of sodium in exchange for potassium and hydrogen. It is not a competitive antagonist of mineralocorticoids, and a potassium-conserving effect is observed in patients with Addison disease (ie, without aldosterone).

Amiloride (Midamor)

This agent is a pyrazine-carbonyl-guanidine unrelated chemically to other known antikaliuretic (potassium-sparing) or diuretic agents. It is a potassium-sparing drug that, compared with thiazide diuretics, possesses weak natriuretic, diuretic, and antihypertensive activity.

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