What is the role of transtubular potassium gradient (TTKG) in the diagnosis of hypokalemia (low potassium level)?

Updated: Dec 06, 2018
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The TTKG was developed to account for the potentially confounding effect of urine concentration on the interpretation of the urine potassium concentration. [48, 49] In effect, the TTKG represents a back-calculation of what the serum-to–tubular fluid ratio of potassium would be at the level of the cortical collecting tubule, where potassium is secreted before urine concentration has occurred.

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