What causes seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME) syndrome?

Updated: Dec 06, 2018
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

This syndrome is caused by mutations in the KCNJ10 gene, which encodes an inwardly rectifying potassium channel. It is inherited in an autosomal recessive fashion. [38]


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