What is thyrotoxic periodic paralysis (TTPP)?

Updated: Dec 06, 2018
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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TTPP is a form of hypokalemic periodic paralysis in which episodes of weakness associated with hypokalemia are seen in individuals with hyperthyroidism. TTPP is most common in Asian males.

The mechanism by which hyperthyroidism produces hypokalemic paralysis is not yet understood, but theories include increased Na-K-ATPase activity, which has been found in patients with both thyrotoxicosis and paralysis. Three single-nucleotide polymorphisms in 3 different regions of the CACNA1S gene have been associated with increased rates of TTPP, compared with normal controls or patients with Graves disease. [37]

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