Can proton pump inhibitors (PPIs) and histamine-2 receptor blockers (eg, cimetidine) cause hypocalcemia?

Updated: Aug 08, 2019
  • Author: Manish Suneja, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print
Answer

Proton pump inhibitors (PPIs) and histamine-2 receptor blockers (eg, cimetidine) reduce gastric acid production; this slows fat breakdown, which is necessary to complex calcium for gut absorption. An association with these medicines and an increased risk for hip fractures in elderly patients has been made because of decreased calcium absorption.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!