When might sodium phosphate bowel preparation cause acute hyperphosphatemia and subsequent hypocalcemia?

Updated: Aug 08, 2019
  • Author: Manish Suneja, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Sodium phosphate preparations, which come in aqueous and tablet forms, are used to cleanse the bowel prior to GI procedures such as colonoscopy. In certain populations, these agents can lead to acute hyperphosphatemia and subsequent hypocalcemia. [26, 27] Risk factors include the following:

  • Renal failure

  • Advanced age

  • Chronic heart failure

  • Hepatic insufficiency

  • Volume depletion

  • Use of angiotensin-converting enzyme (ACE) inhibitors or nonsteroidal anti-inflammatory drugs (NSAIDS)


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