Which medications in the drug class Selective Uric acid Reabsorption Inhibitor (SURI) are used in the treatment of Hyperuricemia?

Updated: Aug 31, 2018
  • Author: James W Lohr, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print
Answer

Selective Uric acid Reabsorption Inhibitor (SURI)

Lesinurad (Zurampic)

Lesinurad is the first selective uric acid reabsorption inhibitor to be approved in the United States. It acts by inhibiting the urate transporter, URAT1, which is responsible for the majority of the renal reabsorption of uric acid. It also inhibits organic anion transporter 4 (OAT4), a uric acid transporter associated with diuretic-induced hyperuricemia. It is indicated in combination with a xanthine oxidase inhibitor for hyperuricemia associated with gout in patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone.


Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!