Which medications in the drug class Urate Oxidase Enzyme (Recombinant) are used in the treatment of Hyperuricemia?

Updated: Nov 03, 2020
  • Author: James W Lohr, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Urate Oxidase Enzyme (Recombinant)

These agents facilitate conversion of urate to a more soluble product, allantoin.

Pegloticase (Krystexxa)

Pegylated uric acid–specific enzyme, which is a polyethylene glycol conjugate of recombinant uricase. Achieves its therapeutic effect by catalyzing oxidation of uric acid to allantoin, thereby lowering serum uric acid levels. Indicated for gout in adults refractory to conventional therapy (ie, serum uric acid levels have failed to normalize and signs and symptoms are inadequately controlled with xanthine oxidase inhibitors at maximum appropriate dose or xanthine oxidase inhibitors are contraindicated).

Rasburicase (Elitek)

A recombinant form (derived from Saccharomyces cerevisiae -synthesized, Aspergillus flavus) of the enzyme urate oxidase, which oxidizes uric acid to allantoin. Indicated for treatment and prophylaxis of severe hyperuricemia associated with the treatment of malignancy. Hyperuricemia causes a precipitant in the kidneys, which leads to acute renal failure. Unlike uric acid, allantoin is soluble and easily excreted by the kidneys. Elimination half-life is 18 h.

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