Which medications in the drug class Alkalinizing Agent, Oral are used in the treatment of Hyperuricemia?

Updated: Aug 31, 2018
  • Author: James W Lohr, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Alkalinizing Agent, Oral

These agents are used to raise the pH in the urine.

Potassium citrate (Citra K, Polycitra K)

Pleasant-tasting oral systemic alkalizer containing potassium citrate and citric acid in a sugar-free base.

Each unit dose packet contains potassium citrate monohydrate 3300 mg and citric acid monohydrate 1002 mg. Each unit dose packet, when reconstituted, supplies the same amount of active ingredients as is contained in 15 mL (1 tablespoonful) Polycitra-K oral solution and provides 30 mEq potassium ion and is equivalent to 30 mEq bicarbonate.

Absorbed and metabolized to potassium bicarbonate, thus acting as a systemic alkalizer. Effects are essentially those of chlorides before absorption and those of bicarbonates subsequently. Oxidation is virtually complete so that < 5% of the potassium citrate is excreted in the urine unchanged.

Highly concentrated and, when administered after meals and before bedtime, allows one to maintain an alkaline urinary pH at all times, usually without necessity of 2 am dose. Alkalinizes urine without producing systemic alkalosis in recommended dosage.


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