How is lesinurad monitored in the treatment of hyperuricemia?

Updated: Aug 31, 2018
  • Author: James W Lohr, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Monotherapy or higher than recommended doses are associated with an increased serum creatinine level. Renal function should be assessed before initiating therapy and periodically thereafter. More frequent monitoring is required for an estimated creatinine clearance (CrCl) below 60 mL/min. Do not initiate therapy if the CrCl is below 45 mL/min and discontinue if CrCl decreases persistently to below 45 mL/min.

Approval was based on three randomized, placebo-controlled studies involving 1537 participants for up to 12 months. Serum uric acid levels were lower in participants treated with lesinurad plus allopurinol or febuxostat than in those who received placebo in combination with a xanthine oxidase inhibitor. [32]


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