Which lab studies are performed in the workup of hyperuricemia?

Updated: Nov 03, 2020
  • Author: James W Lohr, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Laboratory studies may include the following:

  • Serum uric acid

  • Complete blood cell count (CBC): Values may be abnormal in patients with hemolytic anemia, hematologic malignancies, or lead poisoning.

  • Electrolytes, blood urea nitrogen (BUN), and serum creatinine values: These are abnormal in patients with acidosis or renal disease.

  • Liver function tests: These are part of the general workup for patients with a possible malignancy or metabolic disorders; in addition, the results are useful as a baseline if allopurinol is used for treatment

  • Serum glucose level: This may be abnormal in patients with diabetes or glycogen storage diseases.

  • Lipid profile: Results are abnormal in those with dyslipidemia.

  • Calcium and phosphate levels: This measurement is needed for the workup of hyperparathyroidism, sarcoidosis, myeloma, and kidney disease.

  • Thyroid-stimulating hormone level: Obtain this value to help rule out hypothyroidism.

  • Urinary uric acid excretion

  • Fractional excretion of urate on a low-purine diet

  • Spot urine ratio of uric acid to creatinine

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