What is the role of urate/anion exchange in the pathogenesis of hyperuricemia?

Updated: Aug 31, 2018
  • Author: James W Lohr, MD; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

A urate/anion exchanger (URAT1) has been identified in the brush-border membrane of the kidneys and is inhibited by an angiotensin II receptor blocker, losartan. [3] A human organic anion transporter (hOAT1) has been found to be inhibited by both uricosuric drugs and antiuricosuric drugs, [4] while another urate transporter (UAT) has been found to facilitate urate efflux out of the cells. [5] These transporters may account for the reabsorption, secretion, and reabsorption pattern of renal handling of urate.


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