Which medications in the drug class Beta-Blockers, Intrinsic Sympathomimetic are used in the treatment of Hypertension?

Updated: Feb 22, 2019
  • Author: Matthew R Alexander, MD, PhD; Chief Editor: Eric H Yang, MD  more...
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Answer

Beta-Blockers, Intrinsic Sympathomimetic

Agents such as acebutolol and pindolol possess intrinsic sympathomimetic activity (ISA). These agents can be used alone or in combination with other antihypertensive agents, particularly with a thiazide-type diuretic.

Acebutolol (Sectral)

Acebutolol is a cardioselective, beta-adrenoreceptor-blocking agent, which possesses mild intrinsic sympathomimetic activity in its therapeutically effective dose range. Initial dose in uncomplicated, mild to moderate hypertension is 400 mg daily, or twice-daily dosing may be required for adequate 24-hour blood pressure control. Optimal response is usually achieved with dosages of 400 to 800 mg/day; however, some patients have been maintained on as little as 200 mg/day.

Pindolol

Pindolol is indicated in the management of hypertension and can be used alone or with other antihypertensive agents, particularly with a thiazide-type diuretic. The initial dose is 5 mg twice daily alone or in combination with other antihypertensive agents. An antihypertensive response usually occurs within the first week of treatment. Maximal response, however, may take as long as 2 weeks or even longer.


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