Which drug classes are most effective in treating hypertension (high blood pressure) in patients with diabetes?

Updated: Feb 22, 2019
  • Author: Matthew R Alexander, MD, PhD; Chief Editor: Eric H Yang, MD  more...
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In general, patients with diabetes type 1 or type 2 and hypertension have shown clinical improvement with diuretics, angiotensin-converting enzyme inhibitors (ACEIs), beta-blockers, angiotensin receptor blockers (ARBs), and calcium antagonists. [5] Most studies, however, have shown superiority of ACEIs or ARBs over calcium antagonists in diabetic patients. A notable exception is the ACCOMPLISH trial, which showed that, in patients at high risk for cardiovascular events, the combination of benazepril (an ACEI) and amlodipine (a CCB), was superior to the combination of benazepril plus hydrochlorothiazide (a thiazide diuretic). [91] About 60% of the patient cohort had diabetes.

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