What is the trans-tubular potassium gradient (TTKG)?

Updated: Apr 09, 2020
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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The trans-tubular potassium gradient (TTKG) was developed to account for the potentially confounding effect of urine concentration on the interpretation of the urine potassium concentration. In effect, the TTKG back-calculates what the serum-to–tubular fluid ratio of potassium would be at the level of the cortical collecting tubule, where potassium is secreted before urine concentration has occurred.

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