Is measurement of trans-tubular potassium gradient (TTKG) useful in the evaluation of hyperkalemia (high serum potassium level)?

Updated: Apr 09, 2020
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Measurement of the trans-tubular potassium gradient (TTKG) remains widely used as a means of assessing whether decreased renal excretion of potassium is contributing to hyperkalemia. Despite its initial promise, however, recent research has called its accuracy into question, [61] and some experts now recommend that TTKG measurement be abandoned.

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