Which medications can impair renal potassium excretion?

Updated: Apr 09, 2020
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Ask about the use of medications that impair renal potassium excretion, as follows:

  • Potassium-sparing diuretics, which are especially popular in the treatment of cirrhosis and chronic heart failure
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) [58]
  • Angiotensin-converting enzyme (ACE) inhibitors
  • The combination of spironolactone and ACE inhibitors [59]
  • Angiotensin-receptor blockers (ARBs)
  • Direct renin inhibitors (eg, aliskiren)
  • Cyclosporine or tacrolimus
  • Antibiotics (eg, pentamidine and trimethoprim-sulfamethoxazole) [60]
  • Epsilon-aminocaproic acid (EACA) [27]
  • Oral contraceptive agents, such as drosperinone

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