Which medications are used to increase potassium excretion?

Updated: Apr 09, 2020
  • Author: Eleanor Lederer, MD, FASN; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Medications for increasing potassium excretion include the following:

  • IV saline and a loop diuretic (eg, furosemide), in patients with normal renal function

  • An aldosterone analogue, such as 9-alpha fluorohydrocortisone acetate (Florinef), in patients with hyporeninemia or hypoaldosteronism or solid organ transplant patients with chronic hyperkalemia from calcineurin inhibitor use

  • Cation exchange resin such as sodium polystyrene sulfonate (SPS; Kayexalate); patiromer; sodium zirconium cyclosilicate (Lokelma); retention enema for hyperkalemic emergencies, oral for patients with advanced renal failure who are not yet on dialysis or transplant candidates

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