What are the causes of proximal renal tubular acidosis (pRTA) (type II)?

Updated: Oct 18, 2018
  • Author: Sai-Ching Jim Yeung, MD, PhD, FACP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

A summary of the causes of pRTA (type II) is as follows:

  • Primary - Familial or sporadic

  • Dysproteinemic states - Multiple myeloma (pRTA and dRTA), amyloidosis (pRTA and dRTA), light chain disease (LCD), cryoglobulinemia, and monoclonal gammopathy

  • CA-related conditions - Osteopetrosis (carbonic anhydrase II deficiency), acetazolamide, and mafenide

  • Drug or toxic nephropathy - Lead, cadmium, mercury, streptozotocin, outdated tetracycline, and ifosfamide (pRTA and dRTA)

  • Hereditary disorders - Cystinosis, galactosemia, Wilson disease, hereditary fructose intolerance, glycogen storage disease (GSD) type I, tyrosinemia, and Lowe syndrome

  • Interstitial renal conditions - Sjögren syndrome, medullary cystic disease (pRTA and dRTA), Balkan nephropathy, and renal transplant rejection (pRTA and dRTA)

  • Miscellaneous - PNH, malignancies, nephrotic syndrome, and chronic renal vein thrombosis (CRVT)


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