What are GI causes of alkali loss resulting in hyperchloremic acidosis?

Updated: Oct 18, 2018
  • Author: Sai-Ching Jim Yeung, MD, PhD, FACP; Chief Editor: Romesh Khardori, MD, PhD, FACP  more...
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Answer

Other GI conditions associated with external losses of fluids may also lead to large alkali losses. These include enteric fistulas and drainage of biliary, pancreatic, and enteric secretions; ileus secondary to intestinal obstruction, in which up to several liters of alkaline fluid may accumulate within the blocked intestinal lumen; and villous adenomas that secrete fluid with a high bicarbonate content.

Drugs that increase GI bicarbonate loss include calcium chloride, magnesium sulfate, and cholestyramine.


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