What is the pathophysiology of double-positive anti-GBM antibodies and antineutrophilic cytoplasmic antibodies (ANCAs) in patients with Goodpasture syndrome (anti-glomerular basement membrane disease) (anti-GBM)?

Updated: Dec 16, 2020
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Approximately 20%-40% of patients are double-positive for anti-GBM antibodies and antineutrophilic cytoplasmic antibodies (ANCAs). Coexistence of ANCAs (mostly myeloperoxidase MPO-ANCAs) with anti-GBM antibodies is thought to occur when the renal involvement in ANCA vasculitis leads to the exposure of antigens from the basement membrane and the formation of anti-GBM antibodies. [14]


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