Which medications in the drug class Alkylating Agents (Cytotoxic Agents) are used in the treatment of Goodpasture Syndrome?

Updated: Dec 16, 2020
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Alkylating Agents (Cytotoxic Agents)

Alkylating agents bind with DNA and interfere with cell growth and differentiation.

Cyclophosphamide

Cyclophosphamide is chemically related to nitrogen mustards. It is a potent immunosuppressant used as an adjunct to corticosteroids and plasma exchange. This agent interferes with the inflammatory response by decreasing bone marrow response through the interference of DNA cross-linking and decreases anti–glomerular basement membrane (anti-GBM) antibody production.


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