How is Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM) diagnosed?

Updated: Dec 16, 2020
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print

Diffuse alveolar hemorrhage represents a medical emergency, and clinicians must have an expedient approach to its identification. [22] In the appropriate clinical setting (ie, alveolar hemorrhage and urinary findings suggestive of an acute glomerulonephritis), the detection of circulating anti–glomerular basement membrane (anti-GBM) antibodies allows the clinician to make a firm diagnosis of anti-GBM disease. This obviates lung or kidney biopsy.

When the diagnosis remains in doubt, renal biopsy is the best method for detecting anti-GBM antibodies in tissues. Patients in whom the diagnosis of diffuse alveolar hemorrhage remains uncertain should undergo diagnostic bronchoscopy.

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!