What are the signs and symptoms of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Updated: Dec 16, 2020
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Symptoms include the following:

  • Constitutional symptoms (eg, malaise, chills and fever, arthralgias) may precede or develop concurrently with pulmonary or renal manifestations

  • Hemoptysis is the presenting sign when the disease affects the lungs. The level of hemoptysis may vary and, in a small percentage of patients, may be absent. Other pulmonary manifestations include cough, dyspnea, and shortness of breath

  • Massive pulmonary hemorrhage leading to respiratory failure may occur

  • Chest pain is present in less than half of the patients

  • Renal manifestations include hematuria, edema, high blood pressure, and eventually uremia

  • Significant anemia may result from persistent intrapulmonary bleeding

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