What is the role of the alveolar endothelium in the pathogenesis of Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM)?

Updated: Dec 16, 2020
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Vecihi Batuman, MD, FASN  more...
  • Print
Answer

Under normal conditions, the alveolar endothelium is a barrier to the anti–basement membrane antibodies. However, with increased vascular permeability, antibody binding to the basement membrane occurs in the alveoli. Therefore, for the deposition of antibody, an additional nonspecific lung injury that increases alveolar-capillary permeability is required.

A variety of factors that can result in increased alveolar-capillary permeability have been identified. [10] These include the following:

  • Increased capillary hydrostatic pressure
  • High concentrations of inspired oxygen
  • Bacteremia
  • Endotoxemia
  • Exposure to volatile hydrocarbons
  • Upper respiratory infections
  • Tobacco smoking

Did this answer your question?
Additional feedback? (Optional)
Thank you for your feedback!