When was Goodpasture syndrome (anti–glomerular basement membrane disease) (anti-GBM) first identified?

Updated: Dec 16, 2020
  • Author: Pranay Kathuria, MD, FACP, FASN, FNKF; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Ernest Goodpasture first described this disorder in 1919. He reported a case of pulmonary hemorrhage and glomerulonephritis during an influenza epidemic. In 1955, Parkin [3] described 3 cases of lung hemorrhage and nephritis that occurred in the absence of arteritis. In 1958, Stanton and Tang [4] reported a series of young men with pulmonary hemorrhage and glomerulonephritis, similar to Goodpasture's original description.

In the 1950s, Krakower and Greenspon [5] identified GBM as the antigen. In 1967, Lerner, Glassock, and Dixon [6] confirmed that the antibodies taken from the diseased kidneys produced nephritis in experimental animals. The discovery of anti-GBM antibodies led to the understanding of the pathogenesis of Goodpasture syndrome.


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