What causes poststreptococcal glomerulonephritis?

Updated: Dec 16, 2020
  • Author: Duvuru Geetha, MD, MRCP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Acute poststreptococcal glomerulonephritis (APSGN) follows infection with only certain strains of streptococci designated as nephritogenic. The offending organisms are virtually always group A streptococci. APSGN follows pyodermatitis with streptococci M types 47, 49, 55, 2, 60, and 57 and throat infection with streptococci M types 1, 2, 4, 3, 25, 49, and 12.

Less commonly, group C streptococcal infection may result in APSGN. Clusters of cases linked to infection with Streptococcus zooepidemicus have occurred in Brazil, England, and Romania. zooepidemicus is an emerging opportunistic pathogen that is part of the normal respiratory and intestinal flora of horses. [6]


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