Which treatments for immunoglobulin A (IgA) neuropathy do the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines recommend against?

Updated: May 19, 2020
  • Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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KIDGO guidelines recommend against using mycophenolate mofetil, antiplatelet agents, or tonsillectomy for the treatment of IgA nephropathy (grade 2C). In addition, the following treatments are recommended against unless the patient has crescentic IgA nephropathy with rapidly deteriorating kidney function [30] :

  • Corticosteroids combined with cyclophosphamide or azathioprine (grade 2D)
  • Immunosuppressive therapy in patients with GFR 2</sup> (grade 2C)

Crescentic IgA nephropathy is defined by KIDGO as IgA nephropathy with crescents in more than 50% of glomeruli in the renal biopsy with rapidly progressive renal deterioration. [30]

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