What is the role of rituximab in the treatment of immunoglobulin A (IgA) neuropathy?

Updated: Feb 15, 2018
  • Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

CD19 B-cells are increased in IgA nephropathy. However, in a randomized controlled trial in 34 patients with proteinuria and renal dysfunction, treatment with rituximab did not significantly improve renal function or proteinuria over the course of 1 year.  Rituximab had no significant effect on GFR, proteinuria, Gd-IgA1 levels, or on IgG autoantibodies. Consequently, the authors do not recommend use of rituximab in these patients. [38]


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