What is the role of fish oil (omega-3 fatty acids) in the treatment of immunoglobulin A (IgA) neuropathy?

Updated: May 19, 2020
  • Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Fish oil (omega-3 fatty acids) at a dose of 12 g/d has been used, with controversial and conflicting results, but it is frequently administered to patients with declining renal function. [40, 10] Deficiencies of essential fatty acids have been detected in IgA nephropathy, and fish oil is rich in long-chain omega-3 polyunsaturated fatty acids. These produce altered and less biologically effective prostaglandins and leukotrienes, as well as reduced platelet aggregation.Current evidence does not support the use of fish oil as monotherapy, but some physicians combine fish oil with other therapies.

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