What are the signs and symptoms of episodic gross hematuria in immunoglobulin A (IgA) nephropathy?

Updated: Feb 15, 2018
  • Author: Sohail Abdul Salim, MD, FASN, FACP; Chief Editor: Vecihi Batuman, MD, FASN  more...
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Answer

Episodic gross hematuria from IgA nephropathy has the following features:

  • Eighty percent of these episodes are associated with upper respiratory tract infections, mainly acute pharyngotonsillitis; this synchronous association of pharyngitis and macroscopic hematuria has been dubbed synpharyngitic nephritis.
  • Gross hematuria usually appears simultaneously or within the first 48-72 hours after the infection begins; persists less than 3 days; and, in about a third of patients, is accompanied by loin pain, presumably due to renal capsular swelling
  • Seen mostly in children and young adults
  • These patients have a high likelihood of remission.

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